SS-31

SS-31, or elamipretide, is investigated for mitochondrial function in specific disease settings. Its potential applications depend on the condition: the cited primary mitochondrial myopathy trial did not improve its main functional outcomes.

Research focus & potential applications

Mitochondrial function

Cellular bioenergetics

What the research shows

Explore the selected studies, their findings and their limits.

Read the findings & sources

Human study discussed

SS-31, also called elamipretide, has been investigated for mitochondrial function in specific diseases. In the 218-participant MMPOWER-3 trial in primary mitochondrial myopathy, it did not significantly improve the primary walking-distance or fatigue endpoints over 24 weeks versus placebo. That result is specific to this trial and does not establish a general energy or anti-aging benefit.

PubMed · 37268435

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Editorial review: September 23, 2026