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Illustrative vial: Melanotan-1Melanotan-1

Illustrative presentation

INFORMATIONAL REFERENCE

Melanotan-1

Research on afamelanotide examines melanocortin signaling and light-related symptoms in a specific photosensitivity condition. Results for a defined implant and clinical population do not establish the benefits of other preparations.

Research focus & potential applications

Pigmentation biology
Photosensitivity research

What the research shows

Explore the selected studies, their findings and their limits.

Read the findings & sourcesHuman study discussed

Trials of a specific afamelanotide implant in people with erythropoietic protoporphyria measured more time in sunlight without pain compared with placebo. This finding concerns a defined medicine, delivery system and rare photosensitivity disorder. It is not evidence that an uncharacterized Melanotan-1 preparation is a safe tanning product or protects against skin cancer.

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Editorial review: September 23, 2026