LL37

LL-37 is studied in innate immunity, cell signaling and local wound biology. Its potential wound-healing applications have reached human topical studies, with mixed findings that depend on the population and analysis.

Research focus & potential applications

Innate immunity

Wound biology

What the research shows

Explore the selected studies, their findings and their limits.

Read the findings & sources

Human study discussed

LL-37 has been studied for immune-cell signaling and local wound healing. A randomized phase IIb trial using a topical formulation for venous leg ulcers did not show a significant healing advantage in the overall study population. A favorable post-hoc finding in larger ulcers needs confirmation. These results do not establish that systemic LL-37 treats infections or boosts immunity.

Full study · PMC9298190

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Editorial review: September 23, 2026