Adipotide

Adipotide explores a different approach to body composition: targeting the blood supply of fat tissue. Preclinical findings prompted interest in metabolic applications, but kidney toxicity is an important unresolved limitation.

Research focus & potential applications

Fat-tissue biology

Metabolic pathways

What the research shows

Explore the selected studies, their findings and their limits.

Read the findings & sources

Preclinical evidence

In obese rhesus monkeys, adipotide reduced white-fat measures and body weight and improved measures of insulin resistance by targeting blood vessels supplying fat tissue. The same study identified kidney tubular injury and changes in kidney-function markers, making toxicity a central finding. Results in nonhuman primates do not demonstrate safe weight management in humans.

Full study · PMC3666164

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Editorial review: September 23, 2026